ea0016p564 | Obesity | ECE2008
Schaab Michael
, Morawe Daniel
, Klammt Jurgen
, Wilfert Wolfgang
, Thiery Joachim
, Kratzsch Jurgen
Objective: The soluble leptin receptor (sOb-R) is generated by ectodomain shedding of the membrane-associated Ob-R and may modulate leptin action in metabolic dysregulations. The objective of our study was to investigate whether or not sOb-R generation may be induced by indicators of energy availability or metabolic regulators in a cell model.Material and methods: The four human Ob-R isoforms were cloned, characterized by binding experiments with 125-iod...